Louise's spiny mouse is a Horn of Africa species. A diet study in Ethiopia found it eating a mix of plant leaves and stems, seeds, and invertebrates.
The lineage identified with this name is described as reddish brown, with a tail longer than the head and body.
Stomach-content analysis in Ethiopia found leaves and stems, seeds, fruits and invertebrates. Leaves and stems were more abundant in the dry season, while invertebrates increased in the wet season.
An extinction-risk assessment has not been added yet.