The Guianan white-eared opossum occurs in northern and central South America. It was separated from close relatives in a recent taxonomic split, and species-specific information on its appearance and ecology remains sparse.
ADW notes that few descriptions are specific to this species. It presents a robust body, dusty-whitish face with a dark midline, pale ears, and pointed muzzle as likely similarities to the formerly broader D. albiventris group.
It is described as solitary, mainly terrestrial but able to climb, and nocturnal. Daytime refuges include termite mounds, hollow trees, the canopy, leaf nests, and burrows.
An extinction-risk assessment has not been added yet.